Publications
Preprints | 2024 | 2023 |2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
Preprints
Lousada, E., Kliesmete, Z., Janjic, A., Burguière, E., Enard, W., and Schreiweis, C. (2023). Expression profiling of the learning striatum. bioRxiv, 2023.2001.2003.522560. https://www.biorxiv.org/content/biorxiv/early/2023/01/03/2023.01.03.522560.full.pdf
Parekh, S., B. Vieth, C. Ziegenhain, W. Enard, and I. Hellmann, Strategies for quantitative RNA-seq analyses among closely related species. bioRxiv, 2018: p. 297408. https://www.biorxiv.org/content/biorxiv/early/2018/04/09/297408.full.pdf
2024
Jocher, J., Edenhofer, F.C., Müller, S., Janssen, P., Briem, E., Geuder, J., Enard, W. (2024). Generation and characterization of two fibroblast-derived Baboon induced pluripotent stem cell lines. Stem Cell Research 75, 103316. https://doi.org/10.1016/j.scr.2024.103316.
Jocher, J., Edenhofer, F.C., Müller, S., Janssen, P., Briem, E., Geuder, J., Enard, W. (2024). Generation and characterization of two Vervet monkey induced pluripotent stem cell lines derived from fibroblasts. Stem Cell Research 75, 103315. https://doi.org/10.1016/j.scr.2024.103315.
Jocher, J., Edenhofer, F.C., Müller, S., Janssen, P., Briem, E., Lopez-Parra, D.C., Geuder, J., Enard, W. (2024). Generation and characterization of three fibroblast-derived Rhesus Macaque induced pluripotent stem cell lines. Stem Cell Research 74, 103277. https://doi.org/10.1016/j.scr.2023.103277.
2023
Janssen, P., Kliesmete, Z., Vieth, B., Adiconis, X., Simmons, S., Marshall, J., McCabe, C., Heyn, H., Levin, J.Z., Enard, W., and Hellmann, I. (2023). The effect of background noise and its removal on the analysis of single-cell expression data. Genome Biology 24, 140. https://genomebiology.biomedcentral.com/articles/10.1186/s13059-023-02978-x
Kliesmete, Z., Wange, L.E., Vieth, B., Esgleas, M., Radmer, J., Hulsmann, M., Geuder, J., Richter, D., Ohnuki, M., Gotz, M., Hellmann, I., and Enard, W. (2023). Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals. eLife 12. https://www.ncbi.nlm.nih.gov/pubmed/36947129
Bornschein, U., Zeberg, H., Enard, W., Hevers, W., and Paabo, S. (2023). Functional dissection of two amino acid substitutions unique to the human FOXP2 protein. Scientific reports 13, 3747. https://www.ncbi.nlm.nih.gov/pubmed/36879029
Arfelli, V.C., Chang, Y.C., Bagnoli, J.W., Kerbs, P., Ciamponi, F.E., Paz, L., Pankivskyi, S., de Matha Salone, J., Maucuer, A., Massirer, K.B., Enard, W., Kuster, B., Greif, P.A., and Archangelo, L.F. (2023). UHMK1 is a novel splicing regulatory kinase. The Journal of biological chemistry 299, 103041. https://www.ncbi.nlm.nih.gov/pubmed/36803961
2022
Janjic, A., Wange, L.E., Bagnoli, J.W., Geuder, J., Nguyen, P., Richter, D., Vieth, B., Vick, B., Jeremias, I., Ziegenhain, C., Hellmann, I. and Enard. W. (2022). Prime-seq, efficient and powerful bulk RNA-sequencing. Genome Biology 23, 88. doi: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-022-02660-8
Mentz, M., Keay, W., Strobl, C.D., Antoniolli, M., Adolph, L., Heide, M., Lechner, A., Haebe, S., Osterode, E., Kridel, R., Ziegenhain, C., Wange, L.E., Hildebrand, J.A., Shree, T., Silkenstedt, E., Staiger, A.M., Ott, G., Horn, H., Szczepanowski, M., Richter, J., Levy, R., Rosenwald, A., Enard, W., Zimber-Strobl, U., von Bergwelt-Baildon, M., Hiddemann, W., Klapper, W., Schmidt-Supprian, M., Rudelius, M., Bararia, D., Passerini, V., and Weigert, O. (2022). PARP14 is a novel target in STAT6 mutant follicular lymphoma. Leukemia 36, 2281-2292. https://www.ncbi.nlm.nih.gov/pubmed/35851155
Venado, R.E., Wange, L.E., Shen, D., Pinnau, F., Andersen, T.G., Enard, W., and Marin, M. (2022). Tissue-specific regulation of lipid polyester synthesis genes controlling oxygen permeation into Lotus japonicus nodules. Proc Natl Acad Sci U S A 119, e2206291119. https://www.ncbi.nlm.nih.gov/pubmed/36375074
Guillamat-Prats, R., Hering, D., Derle, A., Rami, M., Hardtner, C., Santovito, D., Rinne, P., Bindila, L., Hristov, M., Pagano, S., Vuilleumier, N., Schmid, S., Janjic, A., Enard, W., Weber, C., Maegdefessel, L., Faussner, A., Hilgendorf, I., and Steffens, S. (2022). GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation. Nat Cardiovasc Res 1, 1056-1071. https://www.ncbi.nlm.nih.gov/pubmed/36523570
Zeller, C., Richter, D., Jurinovic, V., Valtierra-Gutierrez, I.A., Jayavelu, A.K., Mann, M., Bagnoli, J.W., Hellmann, I., Herold, T., Enard, W., Vick, B., and Jeremias, I. (2022). Adverse stem cell clones within a single patient's tumor predict clinical outcome in AML patients. J Hematol Oncol 15, 25. https://www.ncbi.nlm.nih.gov/pubmed/35279202
Lutz, K., Musumeci, A., Sie, C., Dursun, E., Winheim, E., Bagnoli, J., Ziegenhain, C., Rausch, L., Bergen, V., Luecken, M.D., Oostendorp, R.A.J., Schraml, B.U., Theis, F.J., Enard, W., Korn, T., and Krug, A.B. (2022). Ly6D(+)Siglec-H(+) precursors contribute to conventional dendritic cells via a Zbtb46(+)Ly6D(+) intermediary stage. Nature communications 13, 3456. https://www.ncbi.nlm.nih.gov/pubmed/35705536
Beer, S., Wange, L.E., Zhang, X., Kuklik-Roos, C., Enard, W., Hammerschmidt, W., Scialdone, A., and Kempkes, B. (2022). EBNA2-EBF1 complexes promote MYC expression and metabolic processes driving S-phase progression of Epstein-Barr virus-infected B cells. Proc Natl Acad Sci U S A 119, e2200512119. https://www.ncbi.nlm.nih.gov/pubmed/35857872
Pekayvaz, K., Leunig, A., Kaiser, R., Joppich, M., Brambs, S., Janjic, A., Popp, O., Nixdorf, D., Fumagalli, V., Schmidt, N., Polewka, V., Anjum, A., Knottenberg, V., Eivers, L., Wange, L.E., Gold, C., Kirchner, M., Muenchhoff, M., Hellmuth, J.C., Scherer, C., Rubio-Acero, R., Eser, T., Deak, F., Puchinger, K., Kuhl, N., Linder, A., Saar, K., Tomas, L., Schulz, C., Wieser, A., Enard, W., Kroidl, I., Geldmacher, C., von Bergwelt-Baildon, M., Keppler, O.T., Munschauer, M., Iannacone, M., Zimmer, R., Mertins, P., Hubner, N., Hoelscher, M., Massberg, S., Stark, K., and Nicolai, L. (2022). Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection. Nature communications 13, 1018. https://www.ncbi.nlm.nih.gov/pubmed/35197461
Wirth, A.K., Wange, L., Vosberg, S., Henrich, K.O., Rausch, C., Ozdemir, E., Zeller, C.M., Richter, D., Feuchtinger, T., Kaller, M., Hermeking, H., Greif, P.A., Senft, D., Jurinovic, V., Bahrami, E., Jayavelu, A.K., Westermann, F., Mann, M., Enard, W., Herold, T., and Jeremias, I. (2022). In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance. Leukemia 36, 2863-2874. https://www.ncbi.nlm.nih.gov/pubmed/36333584
Stolz, P., Mantero, A.S., Tvardovskiy, A., Ugur, E., Wange, L.E., Mulholland, C.B., Cheng, Y., Wierer, M., Enard, W., Schneider, R., Bartke, T., Leonhardt, H., Elsasser, S.J., and Bultmann, S. (2022). TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation. Nucleic acids research 50, 8491-8511. https://www.ncbi.nlm.nih.gov/pubmed/35904814
2021
Bottcher, A., Buttner, M., Tritschler, S., Sterr, M., Aliluev, A., Oppenlander, L., Burtscher, I., Sass, S., Irmler, M., Beckers, J., Ziegenhain, C., Enard, W., Schamberger, A.C., Verhamme, F.M., Eickelberg, O., Theis, F.J., and Lickert, H. (2021). Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates. Nature cell biology 23, 23-31. https://www.ncbi.nlm.nih.gov/pubmed/33398177
Kempf, J., Knelles, K., Hersbach, B.A., Petrik, D., Riedemann, T., Bednarova, V., Janjic, A., Simon-Ebert, T., Enard, W., Smialowski, P., Gotz, M., and Masserdotti, G. (2021). Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2. Cell Rep 36, 109571.https://www.ncbi.nlm.nih.gov/pubmed/34407409
Porquier, A., Tisserant, C., Salinas, F., Glassl, C., Wange, L., Enard, W., Hauser, A., Hahn, M., and Weiberg, A. (2021). Retrotransposons as pathogenicity factors of the plant pathogenic fungus Botrytis cinerea. Genome Biol 22, 225.https://www.ncbi.nlm.nih.gov/pubmed/34399815
Takahashi, K., M. Nakamura, C. Okubo, Z. Kliesmete, M. Ohnuki, M. Narita, A. Watanabe, M. Ueda, Y. Takashima, I. Hellmann, S. Yamanaka, The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency. PLoS Genet. 2021. 17(5): e1009587. https://doi.org/10.1371/journal.pgen.1009587
Kälin R.E., L. Cai, Y. Li, D. Zhao, H. Zhang, J. Cheng, W. Zhang, Y. Wu, K. Eisenhut, P. Janssen, L. Schmitt, W. Enard, F. Michels, C. Flüh, M. Hou, S.V. Kirchleitner, S. Siller, M. Schiemann, I. Andrä, E. Montanez, C. Giachino, V. Taylor, M. Synowitz, J.C. Tonn, L. von Baumgarten, C. Schulz, I. Hellmann, and R. Glass, TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression. Cell Syst. 2021 Feb 9:S2405-4712(21)00036-3. https://www.ncbi.nlm.nih.gov/pubmed/33592194
Geuder, J., L.E. Wange, A. Janjic, J. Radmer, P. Janssen, J.W. Bagnoli, S. Müller, A. Kaul, M. Ohnuki and W. Enard, A non-invasive method to generate induced pluripotent stem cells from primate urine. Scientific Reports 11, 2021. Article number: 3516. https://www.nature.com/articles/s41598-021-82883-0
2020
Shami A., D. Atzler, L.A. Bosmans, H. Winkels, S. Meiler, M. Lacy, C. van Tiel, R. Ta Megens, K. Nitz, J. Baardman, P. Kusters, T. Seijkens, C. Buerger, A. Janjic, C. Riccardi, A. Edsfeldt, C. Monaco, M. Daemen, M.P.J. de Winther, J. Nilsson, C. Weber, N. Gerdes, I. Gonçalves, E. Lutgens, Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans. Eur Heart J. 2020. 41(31): p. 2938-2948. https://pubmed.ncbi.nlm.nih.gov/32728688/
Alterauge, D., J.W. Bagnoli, F. Dahlstrom, B.M. Bradford, N.A. Mabbott, T. Buch, W. Enard, and D. Baumjohann, Continued Bcl6 Expression Prevents the Transdifferentiation of Established Tfh Cells into Th1 Cells during Acute Viral Infection. Cell Rep, 2020. 33(1): p. 108232. https://www.ncbi.nlm.nih.gov/pubmed/33027650
Kober-Hasslacher, M., H. Oh-Strauss, D. Kumar, V. Soberon, C. Diehl, M. Lech, T. Engleitner, E. Katab, V. Fernandez-Saiz, G. Piontek, H. Li, B. Menze, C. Ziegenhain, W. Enard, R. Rad, J.P. Bottcher, H.J. Anders, M. Rudelius, and M. Schmidt-Supprian, c-Rel gain in B cells drives germinal center reactions and autoantibody production. J Clin Invest, 2020. https://www.ncbi.nlm.nih.gov/pubmed/32191641
Kozak, E.L., S. Palit, J.R. Miranda-Rodriguez, A. Janjic, A. Bottcher, H. Lickert, W. Enard, F.J. Theis, and H. Lopez-Schier, Epithelial Planar Bipolarity Emerges from Notch-Mediated Asymmetric Inhibition of Emx2. Curr Biol, 2020. 30(6): p. 1142-1151 e6. https://www.ncbi.nlm.nih.gov/pubmed/32109392
Mereu, E., A. Lafzi, C. Moutinho, C. Ziegenhain, D.J. McCarthy, A. Alvarez-Varela, E. Batlle, Sagar, D. Grun, J.K. Lau, S.C. Boutet, C. Sanada, A. Ooi, R.C. Jones, K. Kaihara, C. Brampton, Y. Talaga, Y. Sasagawa, K. Tanaka, T. Hayashi, C. Braeuning, C. Fischer, S. Sauer, T. Trefzer, C. Conrad, X. Adiconis, L.T. Nguyen, A. Regev, J.Z. Levin, S. Parekh, A. Janjic, L.E. Wange, J.W. Bagnoli, W. Enard, M. Gut, R. Sandberg, I. Nikaido, I. Gut, O. Stegle, and H. Heyn, Benchmarking single-cell RNA-sequencing protocols for cell atlas projects. Nat Biotechnol, 2020. 38(6): p. 747-755. https://www.ncbi.nlm.nih.gov/pubmed/32518403
Garrett, L., Y.J. Chang, K.M. Niedermeier, T. Heermann, W. Enard, H. Fuchs, V. Gailus-Durner, M.H. Angelis, W.B. Huttner, W. Wurst, and S.M. Holter, A truncating Aspm allele leads to a complex cognitive phenotype and region-specific reductions in parvalbuminergic neurons. Transl Psychiatry, 2020. 10(1): p. 66. https://www.ncbi.nlm.nih.gov/pubmed/32066665
Ebinger, S., C. Zeller, M. Carlet, D. Senft, J.W. Bagnoli, W.H. Liu, M. Rothenberg-Thurley, W. Enard, K.H. Metzeler, T. Herold, K. Spiekermann, B. Vick, and I. Jeremias, Plasticity in growth behavior of patients' acute myeloid leukemia stem cells growing in mice. Haematologica, 2020. https://www.ncbi.nlm.nih.gov/pubmed/32029508
LaClair, K.D., Q. Zhou, M. Michaelsen, B. Wefers, M.S. Brill, A. Janjic, B. Rathkolb, D. Farny, M. Cygan, M.H. de Angelis, W. Wurst, M. Neumann, W. Enard, T. Misgeld, T. Arzberger, and D. Edbauer, Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS. Acta Neuropathol, 2020. 140(2): p. 121-142. https://www.ncbi.nlm.nih.gov/pubmed/32562018
Redondo Monte, E., A. Wilding, G. Leubolt, P. Kerbs, J.W. Bagnoli, L. Hartmann, W. Hiddemann, L. Chen-Wichmann, S. Krebs, H. Blum, M. Cusan, B. Vick, I. Jeremias, W. Enard, S. Theurich, C. Wichmann, and P.A. Greif, ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells. Oncogene, 2020. 39(15): p. 3195-3205. https://www.ncbi.nlm.nih.gov/pubmed/32115572
2019
Vieth, B., S. Parekh, C. Ziegenhain, W. Enard, and I. Hellmann, A systematic evaluation of single cell RNA-seq analysis pipelines. Nat Commun, 2019. 10(1): p. 4667. 10.1038/s41467-019-12266-7. https://www.nature.com/articles/s41467-019-12266-7
Wang, S., A.H. Crevenna, I. Ugur, A. Marion, I. Antes, U. Kazmaier, M. Hoyer, D.C. Lamb, F. Gegenfurtner, Z. Kliesmete, C. Ziegenhain, W. Enard, A. Vollmar, and S. Zahler, Actin stabilizing compounds show specific biological effects due to their binding mode. Sci Rep, 2019. 9(1): p. 9731. https://www.ncbi.nlm.nih.gov/pubmed/31278311
Wang, S., F.A. Gegenfurtner, A.H. Crevenna, C. Ziegenhain, Z. Kliesmete, W. Enard, R. Muller, A.M. Vollmar, S. Schneider, and S. Zahler, Chivosazole A Modulates Protein-Protein Interactions of Actin. J Nat Prod, 2019. https://www.ncbi.nlm.nih.gov/pubmed/31260301
Schreiweis, C., T. Irinopoulou, B. Vieth, L. Laddada, F. Oury, E. Burguiere, W. Enard, and M. Groszer, Mice carrying a humanized Foxp2 knock-in allele show region-specific shifts of striatal Foxp2
expression levels. Cortex, 2019. https://www.ncbi.nlm.nih.gov/pubmed/30808549
Gunz, P., A.K. Tilot, K. Wittfeld, A. Teumer, C.Y. Shapland, T.G.M. van Erp, M. Dannemann, B. Vernot, S. Neubauer, T. Guadalupe, G. Fernandez, H.G. Brunner, W. Enard, J. Fallon, N. Hosten, U. Volker, A. Profico, F. Di Vincenzo, G. Manzi, J. Kelso, B. St Pourcain, J.J. Hublin, B. Franke, S. Paabo, F. Macciardi, H.J. Grabe, and S.E. Fisher, Neandertal Introgression Sheds Light on Modern Human Endocranial Globularity. Curr Biol, 2019. 29(1): p. 120-127 e5. https://www.ncbi.nlm.nih.gov/pubmed/30554901
Bagnoli, J.W., L.E. Wange, A. Janjic, and W. Enard, Studying Cancer Heterogeneity by Single-Cell RNA Sequencing. Methods Mol Biol, 2019. 1956: p. 305-319. https://www.ncbi.nlm.nih.gov/pubmed/30779041
2018
Medvedeva, V.P., M.A. Rieger, B. Vieth, C. Mombereau, C. Ziegenhain, T. Ghosh, A. Cressant, W. Enard, S. Granon, J.D. Dougherty, and M. Groszer, Altered social behavior in mice carrying a cortical Foxp2 deletion. Hum Mol Genet, 2018. https://www.ncbi.nlm.nih.gov/pubmed/30357341
Gegenfurtner, F.A., Zisis, T., Danaf, N.A., Schrimpf, W., Kliesmete, Z., Ziegenhain, C., Enard, W., Kazmaier, U., Lamb, D.C., Vollmar, A.M., Zahler, S. 2018. Transcriptional efects of actin‐binding compounds: the cytoplasm sets the tone. Cel. Mol. Life Sci. doi:10.1007/s00018-018-2919-4
W. Bagnoli, J.W., Ziegenhain, C., Janjic, A., Wange, L.E., Vieth, B., Parekh, S., Geuder, J., Hellmann I. & Enard W. 2018. Sensitive and powerful single-cell RNA sequencing using mcSCRB-seq. Nat. Communications. 9. doi:10.1038/s41467-018-05347-6
Nakai, R., Ohnuki, M., Kuroki, K., Ito, H., Hirai, H., Kitajima, R., Fujimoto, T., Nakagawa, M., Enard, W., & Imamura, M. 2018. Derivation of induced pluripotent stem cells in Japanese macaque (Macaca fuscata). Nat. Sci. Rep. 8. https://doi.org/10.1038/s41598-018-30734-w
Gegenfurtner, F.A., Jahn, B., Wagner, H., Ziegenhain, C., Enard, W., Geistlinger, L., ..., Zahler, S. 2018. Micropatterning as a tool to identify regulatory triggers and kinetics of actin-mediated endothelial mechanosensing. J. Cell Sci. 131. http://jcs.biologists.org/content/131/10/jcs212886
Parekh, S., Ziegenhain, C., Vieth, B., Enard, W. & Hellmann, I. 2018. zUMIs - A fast and flexible pipeline to process RNA sequencing data with UMIs. Gigascience. doi:10.1093/gigascience/giy059
Ziegenhain, C., Vieth, B., Parekh, S., Hellmann, I. & Enard, W. 2018. Quantitative single-cell transcriptomics. Brief. Funct. Genomics. doi:10.1093/bfgp/ely009
Mueller, S., Engleitner, T., Maresch, R., Zukowska, M., Lange, S., Kaltenbacher, T., … , Enard, W., Schmid, R.M., Yang, F., Unger, K., Schneider, G., Varela, I., Bradley, A., Saur, D., Rad, R. 2018. Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes. Nature, 554(7690), 62–68. https://doi.org/10.1038/nature25459
2017
Regev, A., Teichmann, S., Lander, E., Amit, I., Benoist, C., Birney, E., ..., Enard, W., Human Cell Atlas Meeting Participants, et al. 2017. Science Forum: The Human Cell Atlas. eLife 6 (December). https://doi.org/10.7554/eLife.27041.
Garz, A., Wolf, S., Grath, S., Gaidzik, V., Habringer, S., Vick, B., Rudelius, M., Ziegenhain, C., Herold, S., Weickert, M., Smets, M., Peschel, C., Oostendorp, R., Bultmann, S., Jeremias, I., Thiede, C., Döhner, K., Keller, U., Götze, K. 2017. Azacitidine Combined with the Selective FLT3 Kinase Inhibitor Crenolanib Disrupts Stromal Protection and Inhibits Expansion of Residual Leukemia-Initiating Cells in FLT3 -ITD AML with Concurrent Epigenetic Mutations. Oncotarget. https://doi.org/10.18632/oncotarget.21877.
Krendl, C., Shaposhnikov, D., Rishko, V., Ori, C., Ziegenhain, C., Sass, S., Simon, L., ..., Enard, W., Theis, F., Drukker, M. 2017. GATA2/3-TFAP2A/C Transcription Factor Network Couples Human Pluripotent Stem Cell Differentiation to Trophectoderm with Repression of Pluripotency. Proceedings of the National Academy of Sciences of the United States of America 114 (45):E9579–88. http://www.pnas.org/content/114/45/E9579.long#ack-1
Vieth, B., Ziegenhain, C., Parekh, S., Enard, W., Hellmann, I. (2017) powsimR: Power analysis for bulk and single cell RNA-seq experiments. Bioinformatics 33 (21):3486-3488. http://dx.doi.org/10.1093/bioinformatics/btx435
Witzel, M., Petersheim, D., Fan, Y., Bahrami, E., Racek, T., Rohlfs, M., Puchałka, J., ..., Ziegenhain, C., Enard, W., ..., Klein, C. 2017. Chromatin-Remodeling Factor SMARCD2 Regulates Transcriptional Networks Controlling Differentiation of Neutrophil Granulocytes. Nature Genetics 49 (5):742–52. http://dx.doi.org/10.1038/ng.3833
Ziegenhain, C., Vieth, B., Parekh, S., Reinius, B., Guillaumet-Adkins, A., Smets, M., Leonhardt, H., Heyn, H., Hellmann, I. and Enard, W. (2017) Comparative Analysis of Single-Cell RNA Sequencing Methods. Molecular Cell 65 (4): 631–43.e4. http://www.sciencedirect.com/science/article/pii/S1097276517300497
Nissen, J., Lykke, K., Bryk, J., Stridh, M., Zaganas, I., Skytt, D., Schousboe, A., Bak, L., Enard, W., Pääbo, S., Waagepetersen, H. 2017. Expression of the Human Isoform of Glutamate Dehydrogenase, hGDH2, Augments TCA Cycle Capacity and Oxidative Metabolism of Glutamate during Glucose Deprivation in Astrocytes. Glia 65 (3):474–88. http://dx.doi.org/10.1002/glia.23105
Schreck, C., Istvanffy, R., Ziegenhain, C., Sippenauer, T., Ruf, F., Henkel, L., Gartner, F., Vieth, B., Florian, M.C., Mende, N., Taubenberger, A., Prendergast, A., Wagner, A., Pagel, C., Grziwok, S., Gotze, K.S., Guck, J., Dean, D.C., Massberg, S., Essers, M., Waskow, C., Geiger, H., Schiemann, M., Peschel, C., Enard, W., and Oostendorp, R.A. (2017). Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells. The Journal of experimental medicine 214, 165-181. http://jem.rupress.org/content/214/1/165.long
2016
Chen, Y.C., Kuo, H.Y., Bornschein, U., Takahashi, H., Chen, S.Y., Lu, K.M., Yang, H.Y., Chen, G.M., Lin, J.R., Lee, Y.H., Chou, Y.C., Cheng, S.J., Chien, C.T., Enard, W., Hevers, W., Paabo, S., Graybiel, A.M., and Liu, F.C. (2016). Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c. Nature neuroscience 19, 1513-1522. http://www.nature.com/neuro/journal/v19/n11/full/nn.4380.html#abstract
Li, Q., Guo, S., Jiang, X., Bryk, J., Naumann, R., Enard, W., Tomita, M., Sugimoto, M., Khaitovich, P., and Paabo, S. (2016). Mice carrying a human GLUD2 gene recapitulate aspects of human transcriptome and metabolome development. Proc Natl Acad Sci U S A 113, 5358-5363. http://www.pnas.org/content/113/19/5358.abstract
Huber, C.D., DeGiorgio, M., Hellmann, I., and Nielsen, R. (2016). Detecting recent selective sweeps while controlling for mutation rate and background selection. Molecular ecology 25, 142-156. http://onlinelibrary.wiley.com/wol1/doi/10.1111/mec.13351/abstract
Nissen, J.D., Lykke, K., Bryk, J., Stridh, M.H., Zaganas, I., Skytt, D.M., Schousboe, A., Bak, L.K., Enard, W., Paabo, S., and Waagepetersen, H.S. (2016). Expression of the human isoform of glutamate dehydrogenase, hGDH2, augments TCA cycle capacity and oxidative metabolism of glutamate during glucose deprivation in astrocytes. Glia 1098-1136. doi:10.1002/glia.23105. http://onlinelibrary.wiley.com/wol1/doi/10.1002/glia.23105/abstract
Ebinger, S.*, Ozdemir, E.Z.*, Ziegenhain, C.*, Tiedt, S.*, Castro Alves, C.*, Grunert, M., Dworzak, M., Lutz, C., Turati, V.A., Enver, T., Horny, H.P., Sotlar, K., Parekh, S., Spiekermann, K., Hiddemann, W., Schepers, A., Polzer, B., Kirsch, S., Hoffmann, M., Knapp, B., Hasenauer, J., Pfeifer, H., Panzer-Grumayer, R., Enard, W., Gires, O., and Jeremias, I. (2016). Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia. Cancer cell 30, 849-862. http://www.sciencedirect.com/science/article/pii/S1535610816305086
Enard, W. (2016). The Molecular Basis of Human Brain Evolution. Current Biology Volume 20, Issue 20: pR1109–R1117. http://www.cell.com/current-biology/abstract/S0960-9822(16)31081-8
Ziegenhain, C., Parekh, S., Vieth, B., Smets, M., Leonhardt, H., Hellmann, I., and Enard, W. (2016). Comparative analysis of single-cell RNA-sequencing methods. http://biorxiv.org/content/early/2016/01/05/035758
Parekh, S., Ziegenhain, C., Vieth, B., Enard, W., and Hellmann, I. (2016). The impact of amplification on differential expression analyses by RNA-seq. Scientific Reports 6, Article number:25533. http://www.nature.com/articles/srep25533
DeGiorgio, M., Huber, C.D., Hubisz, M.J., Hellmann, I., and Nielsen, R. (2016). SWEEPFINDER2: Increased sensitivity, robustness, and flexibility. Bioinformatics. http://bioinformatics.oxfordjournals.org/content/early/2016/02/18/bioinformatics.btw051.abstract
2015
Humphrey, S.J., Azimifar, S.B., and Mann, M. (2015). High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics. Nature Biotechnology 33, 990-995. http://www.ncbi.nlm.nih.gov/pubmed/26280412
Ohnuki, M., and Takahashi, K. (2015). Present and future challenges of induced pluripotent stem cells. Philos Trans R Soc Lond B Biol Sci 370, 20140367. http://www.ncbi.nlm.nih.gov/pubmed/26416678
Hammerschmidt, K., Schreiweis, C., Minge, C., Paabo, S., Fischer, J., and Enard, W. (2015). A humanized version of Foxp2 does not affect ultrasonic vocalization in adult mice. Genes, brain, and behavior 14, 583-590. http://www.ncbi.nlm.nih.gov/pubmed/26250064
Enard, W. (2015). Human evolution: enhancing the brain. Curr Biol 25, R421-423. http://www.ncbi.nlm.nih.gov/pubmed/25989083
Huber, C., DeGiogio, M., Hellmann, I. and Nielsen, R. (2015). Detecting recent selective sweeps while controlling for mutation rate and background selection. Mol Ecol. http://onlinelibrary.wiley.com/doi/10.1111/mec.13351/abstract
2014
Enard, W. (2014). Mouse models of human evolution. Curr Opin Genet Dev 29C, 75-80. doi: 10.1016/j.gde.2014.08.008
Schreiweis, C., Bornschein, U., Burguiere, E., Kerimoglu, C., Schreiter, S., Dannemann, M., Goyal, S., Rea, E., French, C.A., Puliyadi, R., Groszer, M., Fisher, S.E., Mundry, R., Winter, C., Hevers, W., Paabo, S., Enard*, W., and Graybiel*, A.M. (2014). Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance. Proc Natl Acad Sci USA. http://www.ncbi.nlm.nih.gov/pubmed/25225386
Huber, C.D., Nordborg, M., Hermisson, J., and Hellmann, I. (2014). Keeping it Local: Evidence for Positive Selection in Swedish Arabidopsis thaliana. Molecular biology and evolution. http://www.ncbi.nlm.nih.gov/pubmed/25158800
Enard, W. (2014). Comparative genomics of brain size evolution. Front. Hum. Neursci. 8:345, doi:10.3389/fnhum.2014.00345.
Wunderlich, S., Kircher, M., Vieth, B., Haase, A., Merkert, S., Beier, J., Göhring, G., Glage, S., Schambach, A., Curnow, WE.C., Pääbo, S., Martin, U., and Enard, W. (2014). Primate iPS cells as tools for evolutionary analyses. Stem Cell Research, http://dx.doi.org/10.1016/j.scr.2014.02.001.
Prufer, K., Racimo, F., Patterson, N., Jay, F., Sankararaman, S., Sawyer, S., Heinze, A., Renaud, G., Sudmant, P.H., de Filippo, C., Li, H., Mallick, S., Dannemann, M., Fu, Q., Kircher, M., Kuhlwilm, M., Lachmann, M., Meyer, M., Ongyerth, M., Siebauer, M., Theunert, C., Tandon, A., Moorjani, P., Pickrell, J., Mullikin, J.C., Vohr, S.H., Green, R.E., Hellmann, I., Johnson, P.L., Blanche, H., Cann, H., Kitzman, J.O., Shendure, J., Eichler, E.E., Lein, E.S., Bakken, T.E., Golovanova, L.V., Doronichev, V.B., Shunkov, M.V., Derevianko, A.P., Viola, B., Slatkin, M., Reich, D., Kelso, J., and Paabo, S. (2014). The complete genome sequence of a Neanderthal from the Altai Mountains. Nature 505, 43-49. doi: 10.1038/nature12886
top2013
Long, Q., Rabanal, F.A., Meng, D., Huber, C.D., Farlow, A., Platzer, A., Zhang, Q., Vilhjalmsson, B.J., Korte, A., Nizhynska, V., Voronin, V., Korte, P., Sedman, L., Mandakova, T., Lysak, M.A., Seren, U., Hellmann, I., and Nordborg, M. (2013). Massive genomic variation and strong selection in Arabidopsis thaliana lines from Sweden. Nat Genet 45, 884-890. doi: 10.1038/ng.2678
top2012
Clovis, Y.M., Enard, W., Marinaro, F., Huttner, W.B., and De Pietri Tonelli, D. (2012). Convergent repression of Foxp2 3'UTR by miR-9 and miR-132 in embryonic mouse neocortex: implications for radial migration of neurons. Development 139, 3332-3342, http://www.ncbi.nlm.nih.gov/pubmed/22874921.
Enard, W. (2012). Functional primate genomics--leveraging the medical potential. J Mol Med (Berl) 90, 471-480, http://www.ncbi.nlm.nih.gov/pubmed/22555407.
Prufer, K., Munch, K., Hellmann, I., Akagi, K., Miller, J.R., Walenz, B., Koren, S., Sutton, G., Kodira, C., Winer, R., Knight, J.R., Mullikin, J.C., Meader, S.J., Ponting, C.P., Lunter, G., Higashino, S., Hobolth, A., Dutheil, J., Karakoc, E., Alkan, C., Sajjadian, S., Catacchio, C.R., Ventura, M., Marques-Bonet, T., Eichler, E.E., Andre, C., Atencia, R., Mugisha, L., Junhold, J., Patterson, N, Siebauer, M., Good, J.M., Fischer, A., Ptak, S.E., Lachmann, M., Symer, D.E., Mailund, T., Schierup, M.H., Andres, A.M., Kelso, J., and Paabo, S. (2012). The bonobo genome compared with the chimpanzee and human genomes. Nature 486, 527-531, http://www.ncbi.nlm.nih.gov/pubmed/22722832.
Fietz, S.A., Lachmann, R., Brandl, H., Kircher, M., Samusik, N., Schroder, R., Lakshmanaperumal, N., Henry, I., Vogt, J., Riehn, A., Distler, W., Nitsch, R., Enard, W., Paabo, S., and Huttner, W.B. (2012). Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal. Proc Natl Acad Sci U S A 109, 11836-11841, http://www.ncbi.nlm.nih.gov/pubmed/22753484.
Maricic, T., Gunther, V., Georgiev, O., Gehre, S., Curlin, M., Schreiweis, C., Naumann, R., Burbano, H.A., Meyer, M., Lazuela-Fox, C., de la Rasilla, M., Rosas, A., Gajovic, S., Kelso, J., Enard, W., Schaffner, W., and Paabo, S. (2012). A Recent Evolutionary Change Affects a Regulatory Element in the Human FOXP2 Gene. Mol Biol Evol, http://www.ncbi.nlm.nih.gov/pubmed/23197593.
top2011
Lohmueller, K.E., Albrechtsen, A., Li, Y., Kim, S.Y., Korneliussen, T., Vinckenbosch, N., Tian, G., Huerta-Sanchez, E., Feder, A.F., Grarup, N., Jorgensen, T., Jiang, T., Witte, D.R., Sandbaek, A., Hellmann, I., Lauritzen T., Hansen, T., Pedersen, O., Wang, J., and Nielsen, R. (2011). Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome. PLoS Genet 7, e1002326, http://www.ncbi.nlm.nih.gov/pubmed/22022285.
Enard, W. (2011). FOXP2 and the role of cortico-basal ganglia circuits in speech and language evolution. Curr Opin Neurobiol 21, 415-424, http://www.ncbi.nlm.nih.gov/pubmed/21592779.
Reimers-Kipping, S., Hevers, W., Paabo, S., and Enard, W. (2011). Humanized Foxp2 specifically affects cortico-basal ganglia circuits. Neuroscience 175, 75-84, http://www.ncbi.nlm.nih.gov/pubmed/21111790.
Johnson, P.L., and Hellmann, I. (2011). Mutation rate distribution inferred from coincident SNPs and coincident substitutions. Genome Biol Evol 3, 842-850, http://www.ncbi.nlm.nih.gov/pubmed/21572094.
top2010
Pulvers, J.N., Bryk, J., Fish, J.L., Wilsch-Brauninger, M., Arai, Y., Schreier, D., Naumann, R., Helppi, J., Habermann, B., Vogt, J., Nitsch, R., Toth, A., Enard, W., Paabo, S., and Huttner, W.B. (2010). Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline. Proc Natl Acad Sci U S A 107, 16595-16600, http://www.ncbi.nlm.nih.gov/pubmed/20823249.
Li, Y., Vinckenbosch, N., Tian, G., Huerta-Sanchez, E., Jiang, T., Jiang, H., Albrechtsen, A., Andersen, G., Cao, H., Korneliussen, T., Grarup, N., Guo, Y., Hellmann, I., Jin, X., Li, Q., Liu, J., Liu, X., Sparso, T., Tang, M., Wu, H., Wu, R., Yu, C., Zheng, H., Astrup, A., Bolund, L., Holmkvist, J., Jorgensen, T., Kristiansen, K., Schmitz, O., Schwartz, T.W., Zhang, X., Li, R., Yang, H., Wang, J., Hansen, T., Pedersen, O., Nielsen, R., and Wang, J. (2010). Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. Nat Genet 42, 969-972, http://www.ncbi.nlm.nih.gov/pubmed/20890277.
Pool, J.E., Hellmann, I., Jensen, J.D., and Nielsen, R. (2010). Population genetic inference from genomic sequence variation. Genome Res 20, 291-300, http://www.ncbi.nlm.nih.gov/pubmed/20067940.
Staubert, C., Boselt, I., Bohnekamp, J., Rompler, H., Enard, W., and Schoneberg, T. (2010). Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS One 5, e11133, http://www.ncbi.nlm.nih.gov/pubmed/20559446.
top2009
Xia, Q., Guo, Y., Zhang, Z., Li, D., Xuan, Z., Li, Z., Xia, Q., Guo, Y., Zhang, Z., Li, D., Xuan, Z., Li, Z., Dai, F., Li, Y., Cheng, D., Li, R., Cheng, T., Jiang, T., Becquet, C., Xu, X., Liu, C., Zha, X., Fan, W., Lin, Y., Shen, Y., Jiang, L., Jensen, J., Hellmann, I., Tang, S., Zhao, P., Xu, H., Yu, C., Zhang, G., Li, J., Cao, J., Liu, S., He, N., Zhou, Y., Liu, H., Zhao, J., Ye, C., Du, Z., Pan, G., Zhao, A., Shao, H., Zeng, W., Wu, P., Li, C., Pan, M., Li, J., Yin, X., Li, D., Wang, J., Zheng, H., Wang, W., Zhang, X., Li, S., Yang, H., Lu, C., Nielsen, R., Zhou, Z., Wang, J., Xiang, Z., Wang, J. (2009). Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science 326, 433-436, http://www.ncbi.nlm.nih.gov/pubmed/19713493.
Ptak, S.E., Enard, W., Wiebe, V., Hellmann, I., Krause, J., Lachmann, M., and Paabo, S. (2009). Linkage disequilibrium extends across putative selected sites in FOXP2. Mol Biol Evol 26, 2181-2184, http://www.ncbi.nlm.nih.gov/pubmed/19608635.
Dannemann, M., Lorenc, A., Hellmann, I., Khaitovich, P., and Lachmann, M. (2009). The effects of probe binding affinity differences on gene expression measurements and how to deal with them. Bioinformatics 25, 2772-2779, http://www.ncbi.nlm.nih.gov/pubmed/19689957.
Enard, W., Gehre, S., Hammerschmidt, K., Hölter, S.M., Blass, T., Somel, M., Brückner, M.K., Schreiweis, C., Winter, C., Sohr, R., Becker, L., Wiebe, V., Nickel, B., Giger, T., Müller, U., Groszer, M., Adler, T., Aguilar, A., Bolle, I., Calzada-Wack, J., Dalke, C., Ehrhardt, N., Favor, J., Fuchs, H., Gailus-Durner, V., Hans, W., Hölzlwimmer, G., Javaheri, A., Kalaydjiev, S., Kallnik, M., Kling, E., Kunder, S., Moßbrugger, I., Naton, B., Racz, I., Rathkolb, B., Rozman, J., Schrewe, A., Busch, D.H., Graw, J., Ivandic, B., Klingenspor, M., Klopstock, T., Ollert, M., Quintanilla-Martinez, L., Schulz, H., Wolf, E., Wurst, W., Zimmer, A., Fisher, S.E., Morgenstern, R., Arendt, T., Hrabé de Angelis, M., Fischer, J., Schwarz, J., and Pääbo, S. (2009). A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell 137, 961-971, http://www.ncbi.nlm.nih.gov/pubmed/19490899.
Nielsen, R., Hubisz, M.J., Hellmann, I., Torgerson, D., Andres, A.M., Albrechtsen, A., Gutenkunst, R., Adams, M.D., Cargill, M., Boyko, A., Indap, A., Bustamante, C.D., and Clark, A.G. (2009). Darwinian and demographic forces affecting human protein coding genes. Genome Res 19, 838-849, http://www.ncbi.nlm.nih.gov/pubmed/19279335.
top2008
Wang, J., Wang, W., Li, R., Li, Y., Tian, G., Goodman, L., Fan, W., Zhang, J., Li, J., Zhang, J., Guo, Y., Feng, B., Li, H., Lu, Y., Fang, X., Liang, H., Du, Z., Li, D., Zhao, Y., Hu, Y., Yang, Z., Zheng, H., Hellmann, I., Inouye, M., Pool, J., Yi, X., Zhao, J., Duan, J., Zhou, Y., Qin, J., Ma, L., Li, G., Yang, Z., Zhang, G., Yang, B., Yu, C., Liang, F., Li, W., Li, S., Li, D., Ni, P., Ruan, J., Li, Q., Zhu, H., Liu, D., Lu, Z., Li, N., Guo, G., Zhang, J., Ye, J., Fang, L., Hao, Q., Chen, Q., Liang, Y., Su, Y., San, A., Ping, C., Yang, S., Chen, F., Li, L., Zhou, K., Zheng, H., Ren, Y., Yang, L., Gao, Y., Yang, G., Li, Z., Feng, X., Kristiansen, K., Wong, G.K., Nielsen, R., Durbin, R., Bolund, L., Zhang, X., Li, S., Yang, H., and Wang J. (2008). The diploid genome sequence of an Asian individual. Nature 456, 60-65, http://www.ncbi.nlm.nih.gov/pubmed/18987735.
Groszer, M., Keays, D.A., Deacon, R.M., de Bono, J.P., Prasad-Mulcare, S., Gaub, S., Baum, M.G., French, C.A., Nicod, J., Coventry, J.A., Enard, W., Fray, M., Brown, S.D., Nolan, P.M., Pääbo, S., Channon, K.M., Costa, R.M., Eilers, J., Ehret, G., Rawlins, J.N., and Fisher, S.E. (2008). Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits. Curr Biol 18, 354-362, http://www.ncbi.nlm.nih.gov/pubmed/18328704.
Hellmann, I., Mang, Y., Gu, Z., Li, P., de la Vega, F.M., Clark, A.G., and Nielsen, R. (2008). Population genetic analysis of shotgun assemblies of genomic sequences from multiple individuals. Genome Res 18, 1020-1029, http://www.ncbi.nlm.nih.gov/pubmed/18411405.
top2007
Krause, J., Lalueza-Fox, C., Orlando, L., Enard, W., Green, R.E., Burbano, H.A., Hublin, J.J., Hänni, C., Fortea, J., de la Rasilla, M., Bertranpetit, J., Rosas, A., and Paabo, S. (2007). The derived FOXP2 variant of modern humans was shared with Neandertals. Curr Biol 17, 1908-1912, http://www.ncbi.nlm.nih.gov/pubmed/17949978.
Nielsen, R., Hellmann, I., Hubisz, M., Bustamante, C., and Clark, A.G. (2007). Recent and ongoing selection in the human genome. Nat Rev Genet 8, 857-868, http://www.ncbi.nlm.nih.gov/pubmed/17943193.
Francks, C., Maegawa, S., Lauren, J., Abrahams, B.S., Velayos-Baeza, A., Medland, S.E., Colella, S., Groszer, M., McAuley, E.Z., Caffrey, T.M., Timmusk, T., Pruunsild, P., Koppel, I., Lind, P.A., Matsumoto-Itaba, N., Nicod, J., Xiong, L., Joober, R., Enard, W., Krinsky, B., Nanba, E., Richardson, A.J., Riley, B.P., Martin, N.G., Strittmatter, S.M., Möller, H.J., Rujescu, D., St Clair, D., Muglia, P., Roos, J.L., Fisher, S.E., Wade-Martins, R., Rouleau, G.A., Stein, J.F., Karayiorgou, M., Geschwind, D.H., Ragoussis, J., Kendler, K.S., Airaksinen, M.S., Oshimura, M., DeLisi, L.E., and Monaco, A.P. (2007). LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Mol Psychiatry 12, 1129-1139, 1057, http://www.ncbi.nlm.nih.gov/pubmed/17667961.
Timpson, N., Heron, J., Smith, G.D., and Enard, W. (2007). Comment on papers by Evans et al. and Mekel-Bobrov et al. on Evidence for Positive Selection of MCPH1 and ASPM. Science 317, 1036; author reply 1036, http://www.ncbi.nlm.nih.gov/pubmed/17717170.
Weber, M., Hellmann, I., Stadler, M.B., Ramos, L., Paabo, S., Rebhan, M., and Schubeler, D. (2007). Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet 39, 457-466, http://www.ncbi.nlm.nih.gov/pubmed/17334365.
Prufer, K., Muetzel, B., Do, H.H., Weiss, G., Khaitovich, P., Rahm, E., Paabo, S., Lachmann, M., Enard, W. (2007). FUNC: a package for detecting significant associations between gene sets and ontological annotations. BMC Bioinformatics 8, 41, http://www.ncbi.nlm.nih.gov/pubmed/17284313.
top2006
Khaitovich, P., Enard, W., Lachmann, M., and Paabo, S. (2006a). Evolution of primate gene expression. Nat Rev Genet 7, 693-702, http://www.ncbi.nlm.nih.gov/pubmed/16921347.
Khaitovich, P., Tang, K., Franz, H., Kelso, J., Hellmann, I., Enard, W., Lachmann, M., and Paabo, S. (2006b). Positive selection on gene expression in the human brain. Curr Biol 16, R356-358, http://www.ncbi.nlm.nih.gov/pubmed/16618540.
Goidts, V., Armengol, L., Schempp, W., Conroy, J., Nowak, N., Muller, S., Cooper, D.N., Estivill, X., Enard, W., Szamalek, J.M., Hameister, H., and Kehrer-Sawatzki, H. (2006). Identification of large-scale human-specific copy number differences by inter-species array comparative genomic hybridization. Hum Genet 119, 185-198, http://www.ncbi.nlm.nih.gov/pubmed/16395594.
Fish, J.L., Kosodo, Y., Enard, W., Paabo, S., and Huttner, W.B. (2006). Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells. Proc Natl Acad Sci U S A 103, 10438-10443, http://www.ncbi.nlm.nih.gov/pubmed/16798874.
top2005
Khaitovich, P., Hellmann, I., Enard, W., Nowick, K., Leinweber, M., Franz, H., Weiss, G, Lachmann, M., and Paabo, S. (2005). Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees. Science 309, 1850-1854, http://www.ncbi.nlm.nih.gov/pubmed/16141373.
Hellmann, I., Prufer, K., Ji, H., Zody, M.C., Paabo, S., and Ptak, S.E. (2005). Why do human diversity levels vary at a megabase scale? Genome Res 15, 1222-1231, http://www.ncbi.nlm.nih.gov/pubmed/16140990.
Woods, C.G., Bond, J., and Enard, W. (2005). Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings. Am J Hum Genet 76, 717-728, http://www.ncbi.nlm.nih.gov/pubmed/15806441.
Heissig, F., Krause, J., Bryk, J., Khaitovich, P., Enard, W., and Paabo, S. (2005). Functional analysis of human and chimpanzee promoters. Genome Biol 6, R57, http://www.ncbi.nlm.nih.gov/pubmed/15998446.
top2004
Watanabe, H., Fujiyama, A., Hattori, M., Taylor, T.D., Toyoda, A., Kuroki, Y., Noguchi, H., BenKahla, A., Lehrach, H., Sudbrak, R., Kube, M., Taenzer, S., Galgoczy, P., Platzer, M., Scharfe, M., Nordsiek, G., Blöcker, H., Hellmann, I., Khaitovich, P., Pääbo, S., Reinhardt, R., Zheng, H.J., Zhang, X.L., Zhu, G.F., Wang, B.F., Fu, G., Ren, S.X., Zhao, G.P., Chen, Z., Lee, Y.S., Cheong, J.E., Choi, S.H., Wu, K.M., Liu, T.T., Hsiao, K.J., Tsai, S.F., Kim, C.G., OOta, S., Kitano, T., Kohara, Y., Saitou, N., Park, H.S., Wang, S.Y., Yaspo, M.L., and Sakaki, Y. (2004). DNA sequence and comparative analysis of chimpanzee chromosome 22. Nature 429, 382-388, http://www.ncbi.nlm.nih.gov/pubmed/15164055.
Khaitovich, P., Weiss, G., Lachmann, M., Hellmann, I., Enard, W., Muetzel, B., Wirkner, U, Ansorge, W., and Paabo, S. (2004a). A neutral model of transcriptome evolution. PLoS Biol 2, E132, http://www.ncbi.nlm.nih.gov/pubmed/15138501.
Enard, W., Fassbender, A., Model, F., Adorjan, P., Paabo, S., and Olek, A. (2004). Differences in DNA methylation patterns between humans and chimpanzees. Curr Biol 14, R148-149, http://www.ncbi.nlm.nih.gov/pubmed/15027464.
Khaitovich, P., Muetzel, B., She, X., Lachmann, M., Hellmann, I., Dietzsch, J., Steigele, S., Do, H.H., Weiss, G., Enard, W., Heissig, F., Arendt, T., Nieselt-Struwe, K., Eichler, E.E., and Paabo, S. (2004b). Regional patterns of gene expression in human and chimpanzee brains. Genome Res 14, 1462-1473, http://www.ncbi.nlm.nih.gov/pubmed/15289471.
Enard, W., and Paabo, S. (2004). Comparative primate genomics. Annu Rev Genomics Hum Genet 5, 351-378, http://www.ncbi.nlm.nih.gov/pubmed/15485353.
top2003
Hellmann, I., Zollner, S., Enard, W., Ebersberger, I., Nickel, B., and Paabo, S. (2003a). Selection on human genes as revealed by comparisons to chimpanzee cDNA. Genome Res 13, 831-837, http://www.ncbi.nlm.nih.gov/pubmed/12727903.
Hellmann, I., Ebersberger, I., Ptak, S.E., Paabo, S., and Przeworski, M. (2003b). A neutral explanation for the correlation of diversity with recombination rates in humans. Am J Hum Genet 72, 1527-1535, http://www.ncbi.nlm.nih.gov/pubmed/12740762.
top2002
Enard, W., Przeworski, M., Fisher, S.E., Lai, C.S., Wiebe, V., Kitano, T., Monaco, A.P., and Paabo, S. (2002a). Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418, 869-872, http://www.ncbi.nlm.nih.gov/pubmed/12192408.
Enard, W., Khaitovich, P., Klose, J., Zollner, S., Heissig, F., Giavalisco, P., Nieselt-Struwe, K., Muchmore, E., Varki, A., Ravid, R., Doxiadis, G.M., Bontrop, R.E., and Paabo, S. (2002b). Intra- and interspecific variation in primate gene expression patterns. Science 296, 340-343, http://www.ncbi.nlm.nih.gov/pubmed/11951044.
top2001
Straube, A., Enard, W., Berner, A., Wedlich-Soldner, R., Kahmann, R., and Steinberg, G. (2001). A split motor domain in a cytoplasmic dynein. Embo J 20, 5091-5100, http://www.ncbi.nlm.nih.gov/pubmed/11566874.