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Cremer T, Cremer M, Hübner B, Silahtaroglu A, Hendzel M, Lanctôt C, Strickfaden H, Cremer C. The Interchromatin Compartment Participates in the Structural and Functional Organization of the Cell Nucleus. Bioessays. 2020 Feb;42(2):e1900132. doi: 10.1002/bies.201900132. PMID: 31994771.

Cremer M, Brandstetter K, Maiser A, Rao SSP, Schmid VJ, Guirao-Ortiz M, Mitra N, Mamberti S, Klein KN, Gilbert DM, Leonhardt H, Cardoso MC, Aiden EL, Harz H, Cremer T. Cohesin depleted cells rebuild functional nuclear compartments after endomitosis. Nat Commun. 2020 Dec 1;11(1):6146. doi: 10.1038/s41467-020-19876-6. PMID: 33262376; PMCID: PMC7708632


Cremer M, Cremer T. Nuclear compartmentalization, dynamics, and function of regulatory DNA sequences. Genes Chromosomes Cancer. 2019 Jul;58(7):427-436. doi: 10.1002/gcc.22714. Epub 2019 Jan 29. PMID: 30520215.


Cremer C, Szczurek A, Strickfaden H, Birk U, Cremer M, Cremer T (2018) Der Zellkern - eine Stadt in der Zelle, Teil 2: Chromatin-Nanoarchitektur und Genregulation. Biologie in unserer Zeit 48(1): 45-53

Cremer T, Cremer M, Cremer C (2018). The 4D Nucleome: Genome compartmentalization in an evolutionary context. Biochemistry (Moscow) 83(4): 313-325


Cremer M, Schmid VJ, Kraus F, Markaki Y, Hellmann I, Maiser A, Leonhardt H, John S, Stamatoyannopoulos J and Cremer T (2017). Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters. Epigenetics Chromatin, 10, 39. PubMed

Schmid VJ, Cremer M, Cremer T (2017). Quantitative analyses of the 3D nuclear landscape recorded with super-resolved fluorescence microscopy. Methods 123: 33-46


Cremer T, Cremer M, Cremer C (2017) Der Zellkern - eine Stadt in der Zelle: Teil 1: Chromosomenterritorien und Chromatindomänen. Biologie in unserer Zeit 46(5): 290-99


Hübner B, Lomiento M, Mammoli F, Illner D, Markaki Y, Ferrari S, Cremer M, Cremer T (2015) Remodeling of nuclear landscapes during human myelopoietic cell differentiation maintains co-aligned active and inactiv nuclear compartments. Epigenetics & Chromatin 8:47

Cremer T, Cremer M, Hübner B, Strickfaden H, Smeets D, Popken J, Sterr M, Markaki J, Rippe K, Cremer C (2015) The 4D nucleome: Evidence for a dynamic nuclear landscape based on co-aligned active and inactive nuclear compartments. FEBS Letters 589: 2931-2943

Popken J, Graf A, Krebs S, Blum H, Schmid VJ, Strauss A, Guengoer T, Zakhartchenko V, Wolf E, Cremer T (2015) Remodeling of the Nuclear Envelope and Lamina during Bovine Preimplantation Development and Its Functional Implications. PLoS ONE 05/2015; 10(5):e0124619.


Popken J, Brero , Koehler D, Schmid VJ, Strauss A, Wuensch A, Guengoer T, Graf A, Krebs S, Blum H, Zakhartchenko V, Wolf E, Cremer T (2014). Functional reprogramming of fibroblast nuclei in cloned bovine embryos is paralleled by major structural remodeling with both striking similarities and differences to nuclear phenotypes of embryos fertilized in vitro. Nucleus 5(6): 555-589

Popken J, Koehler D, Brero A, Wuensch A, Guengoer T, Thormeyer T, Wolf E, Cremer T, Zakhartchenko V (2014). Positional changes of a pluripotency marker gene during structural reorganization of fibroblast nuclei in cloned early bovine embryos. Nucleus 5(6) : 542-554 

Smeets D, Markaki Y, Schmid VJ, Kraus F, Tattermusch A, Cerase A, Sterr M, Fiedler S, Demmerle J, Popken J, Leonhardt H, Brockdorff N, Cremer T, Schermelleh L, Cremer M (2014) Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci. Epigenetics & Chromatin 7:8

Cremer T, Cremer C, Lichter P (2014) Recollections of a scientific journey published in human genetics: from chromosome territories to interphase cytogenetics and comparative genome hybridization. Hum Genet 133: 403-16


Cremer T (2013) Nuclear architecture and function studied in space and time: origin, current state and perspectives (Schleiden lecture at the DGZ meeting March 2013). Cell News 39: 6-13

Hübner B, Cremer T, Neumann J (2013) Correlative microscopy of individual cells – sequential application of microscopic systems with increasing resolution to study the nuclear landscape. Methods Mol Biol 1042: 299-336


Popken J, Sterr M, Markaki Y, Cremer M, Beck A, Dahlhoff M, Habermann FA, Fezert P, Guengoer T, Reichenbach M, Wuensch A, Wolf E, Zakhartchenko V, Cremer T (2012) Studies of nuclear architecture in mammalian pre-implantation embryos and embryonic stem cells using super-resolution fluorescence microscopy. Reprod Fertil Dev 25:200

Markaki Y, Smeets D, Fiedler S, Schmid VJ, Schermelleh L, Cremer T, Cremer M (2012) The potential of 3D-FISH and super-resolution structured illumination microscopy for studies of 3D nuclear architecture. BioEssays 34: 412-26

Cremer M, Markaki Y, Zunhammer A, Cremer C, Cremer T (2012) Chromatin in the Cell Nucleus: Higher-order Organization. Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0005768.pub2

Cremer T, Markaki Y, Hübner B, Zunhammer A, Strickfaden H, Beichmanis S, Heß M, Schermelleh L, Cremer M and Cremer C (2012) Chromosome territory organisation within the nucleus (2012) Advances in Molecular Biology and Medicine (Vol. 1). Epigenetic Regulation and Epigenomics Edited by Robert A. Meyers.Wiley-VCH. Vol 1: 451-483

Kölbl AC, Weigl D, Mulaw M, Thormeyer T, Bohlander SK, Cremer T, Dietzel S (2012) The radial nuclear positioning of genes correlates with features of megabase-sized chromatin domains. Chromosome Res 20: 735-52


Teller K, Illner D, Thamm S, Casas-Delucchi CS, Versteeg R, Indemans M, Cremer T, Cremer M (2011) A top-down analysis of Xa- and Xi-territories reveals differences of higher order structure at ≥20 Mb genomic length scales. Nucleus 2: 465-477

Cremer T & Cremer M (2011) Über ethische Verantwortbarkeit und Gewissensfreiräume (1) Freigabe der Präimplantationsdiagnostik: Ergebnisoffene, genetische Beratung und weltanschauliche Dimension der PID-Debatte. Gyne 32: 28-32 (in German)

Cremer T & Cremer M (2011) Freigabe der Präimplantationsdiagnostik: Über ethische Verantwortbarkeit und Gewissensfreiräume Gyne 32: 20 – 23 (in German)

Strickfaden H, Cremer T, Rippe K, (2011) Higher order chromatin organization and dynamics. In: Genome organization and function in the cell nucleus (K. Rippe ed.), Wiley-VCH

Cremer, T., Zakhartchenko, V. (2011) Nuclear architecture in developmental biology and cell specialisation. Reprod Fert Develop 23: 1-12

Niedojadlo J, Perret-Vivancos C, Kalland K-H, Cmarko D, Cremer T, van Driel R, Fakan S (2011) Transcribed DNA is preferentially located in the perichromatin region of mammalian cell nuclei. Exp Cell Res 317: 433-444

Casas-Delucchi CS, Brero, A, Rahn HP, Solovei I, Wutz A, Cremer T, Leonhardt H, Cardoso MC (2011) Histone acetylation controls the inactive X chromosome replication dynamics. Nat Commun 2: article number 222


Illner D, Zinner R, Handtke V, Rouquette J, Strickfaden H, Lanctot C, Conrad M, Seiler A, Imhof A, Cremer T, Cremer M (2010) Remodeling of nuclear rchitecture by the thiodioxopiperazine metabolite chaetocin. Exp Cell Res 316: 1662-80

Cremer T (2010) Von der Genetik zur Epigenetik und Epigenomforschung – Essay zur Geschichte der Vererbungsforschung und zur Zukunft der prädiktiven Medizin. Leopoldina NF 98, Nr. 361, 87–165

Cremer T and Cremer M (2010) Chromosome territories. Cold Spring Harb. Perspectives in Biology, 2, a003889

Meggendorfer M, Weierich C, Wolff H, Brack-Werner R, Cremer T (2010) Functional nuclear topography of transcriptionally inducible extra-chromosomal transgene clusters. Chromosome Res. 18: 401-417

Németh A, Cones A, Santoyo-Lopez J, Medina I, Montaner D, Péterfia B, Solovei I, Cremer T, Dopazo J, Längst G (2010) Initial Genomics of the Human Nucleolus. PLoS Genet 6(3): e1000889

Postberg J, Lipps, HJ, Cremer T (2010) Evolutionary origin of the cell nucleus and its functional architecture. Essays in Biochemistry: Epigenetics, Disease and Behaviour 48: 1–24

Rouquette J, Cremer C, Cremer T, Fakan S (2010) Functional nuclear architecture studied by microscopy: Present and future. Int Rev Cell Mol Bio 282: 1-156

Strickfaden H, Zunhammer A, van Koningsbruggen S, Koehler D, Cremer T (2010) 4D chromatin dynamics in cycling cells: Theodor Boveri’s hypotheses revisited. Nucleus 1: 284-297

Markaki Y, Gunkel M, Schermelleh L, Beichmanis S, Neumann J, Heidemann M., Leonhardt H, Eick D, Cremer C, Cremer T (2010) Functional nuclear organization of transcription and DNA replication: a topographical marriage between chromatin domains and the interchromatin compartment. Cold Spring Harb Sym Quant. Biol., Nuclear Organization and Function 75: 475-492

Koehler D, Zakhartchenko V, Ketterl N, Wolf E, Cremer T, Brero A (2010) FISH on 3D Preserved Bovine and Murine Preimplantation Embryos. Meth Mol Biol 659: 437-45


Solovei, I, Kreysing M, Lanctot C, Koesem S, Peichl L, Cremer T, Guck J, Joffe B. (2009)Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution. Cell 137: 356-368

Hable V., C. Greubel, A. Bergmaier, P. Reichart, A. Hauptner, R. Krücken, H. Strickfaden, S. Dietzel, T. Cremer, G.A. Drexler, A.A. Friedl and G. Dollinger (2009). The Live Cell Irradiation- and Observation Setup at SNAKE. Nuclear Instruments and Methods in Physics Research B,267 2090-2097

Müller S, Cremer M, Neusser, Grasser F, Cremer T (2009) Quantum dots in multi-colour fluorescence in situ hybridisation: a technical note. Cytogenetics and Genome Research, 124: 351

Koehler D, Zakhartchenko V, Froenicke L, Stone G, Stanyon R, Wolf E, Cremer T, Brero A (2009). Changes of higher order chromatin arrangements during major genome activation in bovine preimplantation embryos. Exp. Cell Res. 315 (12): 2053-63

Alessandro Brero, Ru Hao, Matthias Schieker, Matthias Wierer, Eckhard Wolf, Thomas Cremer and Valeri Zakhartchenko (2009). Differential reprogramming of active and repressive histone modifications following nuclear transfer with rabbit mesenchymal stem cells and adult fibroblasts. Cloning  Stem Cells, 11 (2): 319-29

Hübner B, Strickfaden H, Müller S, Cremer M, Cremer T. Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure. Eur Biophys J. 2009 Jul;38(6):729-47.


Yang, S. Kohler, D. Teller, K. Cremer, T. Le Baccon, P Heard, E. Eils, R. Rohr, K. (2008) Nonrigid registration of 3-d multichannel microscopy images of cell nuclei IEEE Trans Image Process 17: 493-9

Ronneberger, O. Baddeley, D. Scheipl, F. Verveer, P. J. Burkhardt, H. Cremer C, Fahrmeir, L. Cremer, T. Joffe, B. (2008) Spatial quantitative analysis of fluorescently labeled nuclear structures: Problems, methods, pitfalls. Chromosome Res 16: 523-62

Grasser F, Neusser M, Fiegler H, Thormeyer T, Cremer M Carter N, Cremer T, Stefan Müller S (2008,) Replication timing correlated spatial chromatin arrangements in cancer and primate interphase nuclei J Cell Sci 121: 1876-188

Rauch J, Knoch TA, Solovei I, Teller K, Stein S, Buiring K, Horsthemke B, Langowski J, Cremer T, Hausmann M, Cremer C (2008) Light optical precision measurements of the active and inactive Prader-Willi syndrome imprinted regions in human cell nuclei. Differentiation 76: 66-82

Cremer M, Grasser F, Lanctot C, Müller S, Neußer M, Solovei I, Zinner R, Cremer T (2008) Multicolor 3D-FISH for imaging interphase chromosomes. Methods in Molecular Biology “The Nucleus” edited by R. Hancock


Stehle I, Postberg J, Rupprecht T, Cremer T, Jackson DA Lipps H (2007) Establishment and mitotic stability of an extra-chromosomal mammalian replicon. BMC Cell Biology, 8: 33

Mateos-Langerak J, Goetze S, Leonhardt H, Cremer T, van Driel R, Lanctot C (2007) Nuclear architecture: Is it important for genome function and can we prove it? J Cell Biochem PMID: 17786936

Teller K., Solovei I., Buiting K., Horsthemke B., Cremer T.Maintenance of imprinting and nuclear architecture in cycling cells (2007) PNAS, 104: 14970-14975

Zinner  R, Teller K, Versteeg R, Cremer T, Cremer M (2007) Biochemistry meets nuclear architecture: Multicolor immuno-FISH for colocalization analysis of chromosome segments and differentially expressed gene loci with various histone methylations. Advan Enzyme Regul 47:223-41

Tashiro S, Cremer M, Solovei I, Cremer T (2007) Nuclear architecture: Topology and function of chromatin- and non-chromatin nuclear domains. In: Nuclear Dynamics, Molecular Biology and Visualization of the nucleus. Springer, eds. K. Nagata and K. Takeyasu

Merico V, Barbieri J, Zuccotti M, Joffe B, Cremer T, Redi CA, Solovei I, Garagna S (2007) Epigenomic differentiation in mouse preimplantation nuclei of biparental, parthenote and cloned embryos. Chromosome Res 15: 341-360

Christian Lanctôt C, Kaspar C, Cremer (2007) Positioning of the mouse Hox clusters in the nuclei of developing embryos and differentiating embryoid bodies. Exp Cell Res 313: 1449-1459 IF: 3.77

Küpper K, Kölbl A, Biener D, Dittrich S, von Hase J, Thormeyer T, Fiegler H, Carter NP, Speicher MR, Cremer T, Cremer M (2007) Radial Chromatin positioning is shaped by local gene density not by gene expression. Chromosoma 116: 285-306 IF: 4.06

Neusser M, Schubel V, Koch A, Cremer T, Müller S (2007) Evolutionary conserved, cell type and species specific higher order chromatin arrangements in interphase nuclei of primates. . Chromosoma 116: 307-320 IF: 4.06

Lanctôt C., Cheutin T., Cremer M., Cavalli G. and Cremer T. (2007) Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions. Nature Rev. Genet. 8: 104-115.IF: 22.94


Hauptner A, Friedland W, Dietzel S, Drexler GA, Greubel C, Hable V, Strickfaden H, Cremer T, Friedl AA, Krücken R, Paretzke HG and Dollinger G (2006) Spatial Distribution of DNA Double-Strand Breaks from Ion Tracks. In: Ion Beam Science: Solved and Unsolved Problems. Invited lectures presented at a symposium arranged and published by the Royal Danish Academy of Sciences and Letters, Copenhagen, 1– 5 May, 2006. Edited by Peter Sigmund. Matematisk-fysiske Meddelelser 52, p. 59-85. ISSN 0023-3323 ISBN 87-7304-330-3. Free Download PDF (13MB)

Cremer, T, Cremer C. 2006. Rise, fall and resurrection of chromosome territories: a historical perspective Part II. Fall and resurrection of chromosome territories during the 1950s to 1980s. Part III. Chromosome territories and the functional nuclear architecture: experiments and models from the 1990s to the present. Eur J Histochem 50: 223-272 IF: 1.1

Cremer T, Cremer C. 2006a. Rise, fall and resurrection of chromosome territories: a historical perspective. Part I. The rise of chromosome territories. Eur J Histochem 50: 161-176 IF: 1.19

Siwei Yang s, Daniela Köhler D, Kathrin Teller D, Thomas Cremer T, Patricia Le Baccon P, Edith Heard E, Roland Eils R, and Karl Rohr K (2006) Non-rigid Registration of 3D Multi-channel Microscopy Images of Cell Nuclei. In: R. Larsen, M. Nielsen, and J. Sporring (Eds.): MICCAI 2006, LNCS 4190, pp. 907–914. Springer-Verlag Berlin Heidelberg 2006

Albiez H, Cremer M, Tiberi C, Vecchio L, Schermelleh L, Dittrich S, Küpper K, Joffe B, Thormeyer T, von Hase J, Yang S, Rohr K, Leonhardt H, Solovei I, Cremer C, Fakan S,  Cremer T. 2006.  Chromatin domains and the interchromatin compartment form structurally defined and functionally interacting nuclear networks. Chromosome Res 14: 707-733 IF: 3.0

Walter J, Joffe B, Bolzer A, Albiez H, Benedetti PA, Müller S, Speicher MR, Cremer T, Cremer M, Solovei I (2006) Towards many colors in FISH on 3D-preserved interphase nuclei. Cytogenet Genome Res 114: 367-378 IF: 1.99

Cremer T, Cremer M, Dietzel S, Müller S, Solovei 1, Fakan S. 2006. Chromosome territories – a functional nuclear landscape. Curr Opin Cell Biol 18:307–316 IF: 14.29

Hable V, Dollinger G, Greubel C, Hauptner a, Krücken R, Dietzel S, Cremer T, Drexler GA, Friedl AA, Löwe R (2006) Methods for quantitative evaluation of dynamics of repair proteins within irradiated cells. Nuclear Instruments and Methods in Physics Research B 245 (2006) 298–301 IF: 0.94

Hauptner A, Krücken R,  Greubel C, Hable V, Dollinger G, Drexler GA, Deutsch M, Löwe R, Friedl AA, Dietzel S, Strickfaden, Cremer T (2006) DNA-repair protein distribution along the tracks of energetic ions. Radiation Prot Dosimetry 2006 Nov 28; IF: 0.44

Zinner R, Albiez H, Walter, J, Peters, A H F M,  Cremer, T, Cremer, M. 2006. Histone lysine methylation patterns in human cell types are arranged in distinct three-dimensional nuclear zones. Histochem Cell Biol , 125: 3-19 IF: 3.22


Dollinger G, Hable V, Hauptner A, Krücken R, Reichart P, Friedl AA, Drexler G, Cremer T, Diezel S. 2005. Microirradiation of cells with energetic heavy ions. Nuclear Instruments and Methods in Physics. Research Section B. Beam interactions with materials and atoms 231, 195-201.

Brero A, Hariharan P. Easwaran HP, Nowak D, Grunewald I, Cremer T, Leonhardt H, Cristina Cardoso MC. 2005. Methyl CpG–binding proteins induce large-scale chromatin reorganization during terminal differentiation. J Cell Biol 169: 733-743. IF: 10.15

Bolzer, A., Kreth, G., Solovei, I., Koehler, D., Saracoglu S., Fauth, C., Müller, S., Eils, R., Cremer, C., Speicher, M.R., Cremer, T.  (2005) Three-Dimensional Maps of All Chromosomes in Human Male Fibroblast Nuclei and Prometaphase Rosettes. PLoS Biol 3 (5): e157. IF: 14.10

Lux C, Albiez H, Chapman RD, Heidinger M, Meininghaus M, Brack-Werner R, Lang A, Ziegler M, Cremer T, Eick D. 2005. Transition from initiation to promoter proximal pausing requires the CTD of RNA polymerase II. Nucleic Acids Research 33: 5139-5144 IF: 6.31

Postberg J, Alexandrova O, Cremer T, Lipps HJ. 2005. Exploiting nuclear duality of ciliates to analyse topological requirements for DNA replication and transcription. J Cell Science 118: 3973-3983. IF: 6.42

Mayer R, Brero A, von Hase J, Schroeder T, Cremer  T, Dietzel S. 2005.  Common themes and cell type specific variations of higher order chromatin arrangements in the mouse. BMC Cell Biology 6:44 IF: 2.72

Dollinger G, Hable V, Hauptner A, Kruecken R, Reichart P, Friedl AA, Drexler G, Cremer T, Dietzel  S. 2005. Microirradiation of cells with energetic heavy ions. Nuclear Instruments and Methods in Physics Research B 231:195–201. IF: 0.94


Stadler S, Schnapp V, Mayer R, Stein S, Cremer C, Bonifer C, Cremer T, Dietzel, S. 2004. The architecture of chicken chromosome territories changes during differentiation. BMC Cell Biology 5:44 IF: 2.72

Cremer T, Cremer M, Solovei I, Dietzel S. 2004. Variable Chromatinanordnung und ihre Bedeutung für die Genregulation. BIOspektrum 10: 373-377.

Cremer T, Küpper K, Dietzel S, Fakan S. 2004. Higher order chromatin architecture in the cell nucleus: On the way from structure to function. Biology of the Cell 96, 555-567. IF: 4.30

Solovei I, Schermelleh L, Düring K, Engelhardt A, Stein S, von Hase J, Cremer C, Cremer T. 2004. Differences in centromere positioning of cycling and postmitotic human cell types. Chromosoma 112: 410-423. IF: 4.06

Solovei I, Schermelleh L, Albiez H, Cremer T. 2004. Detection of the cell cycle stages in situ in growing cell populations. In: Celis J, editor.Celis Js. Cell Biology Handbook: A Laboratory Manual, 3rd Edition. San Diego: Academic Press, NYP

Solovei I, Grandi N, Knoth R, Volk B, Cremer T. 2004. Postnatal changes of pericentromeric heterochromatin and nucleoli in postmitotic Purkinje cells during murine cerebellum development. Cytogenet Genome Res 105, 302 – 310 IF: 1.99

Cremer M, Zinner R, Stein S, Albiez H, Wagler B, Cremer C, Cremer T. (2004) Three dimensional analysis of histone methylation patterns in normal and tumor cell nuclei. Eur J Histochem. 48:15-28. IF

Hauptner, A., Dietzel, S., Drexler, G. A., Reichart, P., Krücken, R., Cremer, T., Friedl, A. A., Dollinger, G. (2004) Microirradiation of cells with energetic heavy ions. Radiat. Environ. Biophys. 42: 237–245


Alexandrova O, Solovei I, Cremer T, David CN (2003) Replication labeling patterns and chromosome territories typical of mammalian nuclei are conserved in the early metazoan Hydra. Chromosoma. 112:190-200 IF: 4.06

Weierich C, Brero A, Stein S, von Hase J, Cremer C, Cremer T, Solovei I (2003) Three-dimensional arrangements of centromeres and telomeres in nuclei of human and murine lymphocytes. Chromos. Res. 11: 485 – 502    IF: 3.0

Cremer M, Küpper  K, Wagler B, Wizelman L,  von Hase J, Weiland Y, Kreja L, Diebold J, Speicher MR, Cremer T (2003) Inheritance of gene density–related higher order chromatin arrangements in normal and tumor cell nuclei, J. Cell Biol., 162: 809 – 820 IF: 10.15

Walter J, Cremer T, Myagawa K, Tashiro S. 2003. A new system for laser-uv-microirradiation of  living cells. J. Microsc 209: 71 – 75. IF:1.95

Walter J, Schermelleh L, Cremer M, Tashiro S, Cremer T. 2003. Chromosome order changes during mitosis and early G1, but is stably maintained during subsequent interphase stages, J. Cell Biol., 160: 685 – 697. IF: 10.15

Cremer M, Schermelleh L, Solovei I and Cremer T (2003) Cell Cycle: Chromosomal Organization. In: Cooper DN (ed.) Nature Encyclopedia of the Human Genome, vol. 1, pp. 451-457. London: Nature Publishing Group

Cremer T and Cremer C (2003) Chromatin in the Cell Nucleus: Higher-order Organization. In: Cooper DN (ed.) Nature Encyclopedia of  the Human Genome, vol. 1, pp. 514-518. London: Nature Publishing Group


Tanabe H, Habermann F, Solovei I, Cremer M, Cremer T (2002) Non-random radial arrangements of interphase chromosome territories: Evolutionary considerations and functional implications. Mutation Research 504: 37-45

Solovei I, Cavallo A, Schermelleh L, Jaunin F, Scasselati C, Cmarko D, Cremer C, Fakan, S, Cremer T (2002) Spatial preservation of nuclear chromatin architecture during three-dimensional fluorescence in situ hybridization. Exp  Cell Res 276: 10-23

Tanabe H, Müller S, Neusser M, von Hase J, Calcagno E, Cremer M, Solovei, I, Cremer C, Cremer T (2002) Evolutionary conservation of chromosome territory arrangements in cell nuclei from higher primates. Proc Natl Acad  Sciences USA, 99: 4424-4429

Solovei I, Walter J, Cremer M, Habermann F, Schermelleh L, Cremer T. (2002) FISH on three-dimensionally preserved nuclei. In: FISH: a practical approach (B. Beatty , S. Mai and J. Squire, eds.), pp. 119-157. Oxford University press.


Schermelleh, L., Solovei, I., Zink, D., Cremer, T. (2001) Two-color fluorescence labeling of early and mid to late replicating chromatin in living cells. Chromosome Research 9, 77-80

Cremer, T. & Cremer, C. Chromosome Territories, Nuclear Architecture and Gene Regulation in Mammalian Cells. Nature Reviews Genetics 2, 292-301 (2001).

Cremer, M., von Hase, J., Volm, T., Brero, A., Kreth, G., Walter J., Fischer C., Solovei I., Cremer C., Cremer T.  (2001) Non-random radial higher order chromatin arrangements in nuclei of diploid human cells. Chromosome Research 9, 541-547

Haberrmann, F.A., Cremer, M., Walter, J., Kreth, G., von Hase, J. Bauer, K., Wienberg, J., Cremer, C., Cremer, T., Solovei, I. (2001) Arrangements of macro- and microchromosomes in chicken cells. Chromosome Research 9, 569-584 

P. Edelmann, H. Bornfleth, D. Zink, T. Cremer, C. Cremer (2001) Morphology and dynamics of chromosome territories in living cells, Biochimica Biophysica Acta 1551, 29 – 40.


Bornfleth, H., Cremer, C., Cremer, T., Dietzel, S., Edelmann P., Eils R., Jäger, W., Kienle D, Kreth G., Lichter P. , Little G., Münkel, C., Langowski, J., Solovei I., Stelzer E.H.K., Zink D. (2000) Analysis of chromosome territory architecture in the human cell nucleus: overview of data from a collaborative study. In: Genomics and Proteomics. Functional and Computational Aspects, S. Suhai ed., 133 – 140, Kluwer Academic/ Plenum Publishers, New York, Boston, Dordrecht, London, Moscow (2000)

Leonhardt, H., Rahn, H.-P., Weinzierl, P., Sporbert, A., Cremer, T., Zink, D., Cardoso, M.C. (2000) Dynamics of DNA replication factories in living cells. J. Cell Biol. 149, 271-279.

Cremer, T., Kreth, G., Koester, H., Fink, R.H.A., Heintzmann, R., Cremer, M., Solovei, I., Zink, D., Cremer, C. (2000) Chromosome Territories, Interchromatin Domain Compartment and Nuclear Matrix: an Integrated View of the Functional Nuclear Architecture. Crit Rev Eukar Gene 10, 179-212

Tashiro, T., Walther, J., Shinohara, A., Kamada, N., Cremer, T. (2000) Rad51 accumulation at sites of DNA damage and in postreplicative chromatin. J. Cell Biol. 150, 283-291

Solovei I, Kienle D, Little G, Eils R, Savelyeva L, Schwab M, Jäger W, Cremer C, Cremer T (2000) Topology of double minutes (dmins) and homogeneously staining regions (HSRs) in nuclei of human neuroblastoma cell lines. Genes, Chromosomes & Cancer 29, 297-308